anti-NEUROD2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG67106
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NEUROD2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NEUROD2 |
| 抗原物种 | Human |
| 抗原 | Human NEUROD2 Synthesized peptide |
| 偶联标记 | Un-conjugated |
| 別名 | NEUROD2; Neuronal Differentiation 2; BHLHa1; NDRF; NeuroD-Related Factor; Class A Basic Helix-Loop-Helix Protein 1; Neurogenic Differentiation Factor 2; Neurogenic Differentiation 2; Neurogenic Basic-Helix-Loop-Helix Protein; NeuroD2; EIEE72; BHLHA1; DEE72 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NEUROD2 |
| 全名 | Neuronal Differentiation 2 |
| 背景介绍 | This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. |
| 生物功能 | Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter. |
| 细胞定位 | Nucleus |
| 预测分子量 | 41 kDa |
检测图片 (3)
ARG67106 anti-NEUROD2 antibody IHC-P image
Immunohistochemistry: Human tonsil stained with ARG67106 anti-NEUROD2 antibody at 1:200 dilution.
ARG67106 anti-NEUROD2 antibody WB image
Western blot: 293 stained with ARG67106 anti-NEUROD2 antibody.
ARG67106 anti-NEUROD2 antibody WB image
Western blot: COLO205 stained with ARG67106 anti-NEUROD2 antibody at 1:1000 dilution.
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