anti-PDE6B antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG40803
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PDE6B |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PDE6B |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-190 of Human PDE6B (NP_001138763.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; rd1; RP40; CSNBAD2; PDEB; CSNB3; GMP-PDE beta; EC 3.1.4.35 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P23440 Mouse Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Swiss-port # P35913 Human Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta |
|---|---|
| 基因名称 | PDE6B |
| 全名 | phosphodiesterase 6B, cGMP-specific, rod, beta |
| 背景介绍 | Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| 生物功能 | This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme. [UniProt] |
| 细胞定位 | Membrane; Lipid-anchor. [UniProt] |
| 预测分子量 | 98 kDa |
检测图片 (1)
ARG40803 anti-PDE6B antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse retina stained with ARG40803 anti-PDE6B antibody at 1:200 dilution.
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