anti-Pin 1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG55420
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody recognizes Pin 1 |
|---|---|
| 反应物种 | Hu, Ms, Rat, Mk |
| 应用 | IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 855CT1.7.5 |
| 同位型 | IgG1 |
| 靶点名称 | Pin 1 |
| 抗原物种 | Human |
| 抗原 | Purified His-tagged Human Pin1 protein. |
| 偶联标记 | Un-conjugated |
| 別名 | UBL5; PPIase Pin1; DOD; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; EC 5.2.1.8; Rotamase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse brain |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q13526 Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Swiss-port # Q9QUR7 Mouse Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
|---|---|
| 基因名称 | PIN1 |
| 全名 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
| 背景介绍 | Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011] |
| 生物功能 | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner. Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN. [UniProt] |
| 细胞定位 | Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with NEK6 in the nucleus. Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization |
| 研究领域 | Cell Biology and Cellular Response antibody; Neuroscience antibody |
| 预测分子量 | 18 kDa |
| 翻译后修饰 | Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its ability to induce centrosome amplification, chromosome instability and cell transformation. |
检测图片 (2)
ARG55420 anti-Pin 1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human breast section stained with ARG55420 anti-Pin 1 antibody at 1:25 dilution.
ARG55420 anti-Pin 1 antibody WB image
Western blot: 35 µg of Mouse brain lysate stained with ARG55420 anti-Pin 1 antibody.
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