anti-SMARCC1 antibody

Key features and details

  • 产品描述: Mouse Monoclonal antibody recognizes BAF155
  • 反应物种: Hu
  • 应用: WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 同位型: IgG1
  • 靶点名称: SMARCC1
  • 抗原物种: Human
  • 抗原: Purified recombinant human SMARCC1 protein fragments expressed in E.coli.
  • Brand:
CAT.NO. : ARG54105
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Product Details
概述
产品描述Mouse Monoclonal antibody recognizes BAF155
反应物种Hu
应用WB
宿主Mouse
克隆Monoclonal
同位型IgG1
靶点名称SMARCC1
抗原物种Human
抗原Purified recombinant human SMARCC1 protein fragments expressed in E.coli.
偶联标记Un-conjugated
別名SWI/SNF complex subunit SMARCC1; BAF155; BRG1-associated factor 155; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI/SNF complex 155 kDa subunit
应用说明
应用建议
应用推荐稀释比
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量155 kDa
属性
形式Liquid
纯化Affinity purified
缓冲液PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
浓度8 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 6599 Human SMARCC1

Swiss-port # Q92922 Human SWI/SNF complex subunit SMARCC1

基因名称SMARCC1
全名SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
背景介绍Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).May stimulate the ATPase activity of the catalytic subunit of the complex.Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex,a chromatin-remodeling complex recruited by vitamin D receptor (VDR),which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A,are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth by similarity.
生物功能Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). [UniProt]
细胞定位Nucleus.
研究领域Gene Regulation antibody
预测分子量123 kDa
翻译后修饰Phosphorylated on undefined residues at the G2/M transition by ERK1 and other kinases. This may contribute to cell cycle specific inactivation of remodeling complexes containing the phosphorylated protein.
检测图片 (1)
  • ARG54105 anti-SMARCC1 antibody WB image

    Western blot: HeLa cell lysate stained with ARG54105 anti-SMARCC1 antibody at 1:1000 dilution.

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