anti-TIMP2 antibody [3A4]

CAT.NO. : ARG20584

US＄ Please choose

Size:

100 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [3A4] recognizes TIMP2
反应物种	Hu, Zfsh
预测物种	Ms, Rat, Chk, Pig, Rb
应用	IHC-P, IHC-Wmt, WB
宿主	Mouse
克隆	Monoclonal
克隆号	3A4
同位型	IgG2a
靶点名称	TIMP2
抗原物种	Human
抗原	Synthetic peptide from Human TIMP-2 protein and Mouse myeloma Ag8563 cells.
偶联标记	Un-conjugated
別名	TIMP-2; Tissue inhibitor of metalloproteinases 2; CSC-21K; DDC8; Metalloproteinase inhibitor 2

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

阳性对照

IHC: formalin-fixed, paraffin-embedded colonic adenocarcinoma.
Western blot: rhTIMP-2, 400 ng per lane.

属性

形式	Liquid
纯化	Purification with Protein A/G.
缓冲液	PBS and 0.08% Sodium azide
抗菌剂	0.08% Sodium azide
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 7077 Human TIMP2 Swiss-port # P16035 Human Metalloproteinase inhibitor 2
基因名称	TIMP2
全名	TIMP metallopeptidase inhibitor 2
背景介绍	This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
生物功能	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. [UniProt]
预测分子量	24 kDa
翻译后修饰	The activity of TIMP2 is dependent on the presence of disulfide bonds.

检测图片 (3)

ARG20584 anti-TIMP2 antibody [3A4] WB image
Western blot: 400 ng of 1) TIMP-1, and 2) TIMP-2 recombinant protein stained with ARG20584 anti-TIMP2 antibody [3A4].
ARG20584 anti-TIMP2 antibody [3A4] IHC-P image
Immunohistochemistry: wax-embedded Human colon stained with ARG20584 anti-TIMP2 antibody [3A4] at 1:32 dilution.
ARG20584 anti-TIMP2 antibody [3A4] IHC-Wmt image
Immunohistochemistry: whole-mount Zebrafish embryo stained with ARG20584 anti-TIMP2 antibody [3A4].

New Products