CDX2 Rabbit Monoclonal Antibody(ARB826)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6616
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Product Details
Background
CDX2 is a homeobox gene encoding nuclear homeodomain transcriptional factor essential to intestinal organogenesis. CDX2 is crucial for differentiation of epithelium in the intestine, pancreas and biliary tract. CDX2 interacts with the tumour suppressor genes APC and E-cadherin, as well as bcl-2.In the intestine (from duodenum to rectum) CDX2 nuclear protein is demonstrated strongly and uniformly in all types of epithelial cells. In pancreas and biliary tract CDX2 protein is demonstrated in scattered ductal cells. In tumor tissues, CDX2 is positive in the large majority cases of colorectal and appendiceal adenocarcinomas.CDX2 is a relatively sensitive and specific marker for “intestinal” adenocarcinomas. In the classification of (adeno-)carcinomas of the unknown primary, CDX2 is an important marker but should always be included in a panel. Also in order to identify the origin of neuroendocrine tumors, CDX2 is useful in a panel.
Overview
| Target | CDX2 |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 34 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | Q99626 |
| Immunogen | Synthetic peptide corresponding to CDX2 residues within aa1-100 of CDX2 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Nucleus |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18° C-25°C) for 30 minutes |
Data
Immunohistochemical staining of human colonic tissue sections was performed using CDX2 Rabbit Monoclonal Antibody (ARB826).
Immunohistochemical staining of human colorectal carcinoma tissue sections was performed using CDX2 Rabbit Monoclonal Antibody (ARB826).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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