Coxiella burnetii / Q Fever Phase 1 IgG antibody ELISA Kit

Key features and details

产品描述: ARG83055 Coxiella burnetii / Q Fever Phase 1 IgG antibody ELISA Kit is an enzyme immunoassay kit for the qualitative Coxiella burnetii (Q-Fever) Phase 1 in human serum or plasma (citrate, heparin).
反应物种: Hu
应用: ELISA
靶点名称: Coxiella burnetii / Q Fever
偶联标记: HRP
偶联标记说明: Substrate: TMB and read at 450 nm.
灵敏度: diagn. 100 %
检测范围: Cut - off
样品类型: serum, plasma (citrate, heparin)

Brand:

CAT.NO. : ARG83055

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Size:

96 wells

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Product Details

概述

产品描述	ARG83055 Coxiella burnetii / Q Fever Phase 1 IgG antibody ELISA Kit is an enzyme immunoassay kit for the qualitative Coxiella burnetii (Q-Fever) Phase 1 in human serum or plasma (citrate, heparin).
反应物种	Hu
应用	ELISA
靶点名称	Coxiella burnetii / Q Fever
偶联标记	HRP
偶联标记说明	Substrate: TMB and read at 450 nm.
灵敏度	diagn. 100 %
检测范围	Cut - off
样品类型	serum, plasma (citrate, heparin)
样本量	100 µl
精确	Intra-Assay CV: less than 9% Inter-Assay CV: less than 7%
別名	Q fever, Coxiella burnetii, C. burnetii

应用说明

检测时间	~2 hours

属性

形式	96 well
存放说明	Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

背景介绍	The reference standard test for the serologic diagnosis of acute Q fever is the indirect immunofluorescence antibody (IFA) using C. burnetii antigen, performed on paired serum samples to demonstrate a significant (fourfold or more) rise in antibody titers. The first sample should be taken as early in the disease as possible, preferably in the first week of symptoms, and the second sample should be taken 3 to 6 weeks later. In most cases of Q fever, the first IgG IFA titer is typically low, or “negative,” and the second typically shows a fourfold or greater increase in IgG antibody levels. A negative test during the first week of illness does not rule out Q fever as a cause of illness. There are two distinct antigenic phases (phase I and phase II) to which humans develop antibody responses. In acute infection, an antibody response to C. burnetii phase II antigen is predominant and is higher than antibody levels to phase I antigen; the reverse is true in chronic infection which is associated with a rising phase I IgG titer that may be higher than phase II IgG. IgM antibodies usually rise at the same time as IgG, near the end of the first week of illness, and remain elevated for months or longer and therefore provide limited diagnostic value on their own. Furthermore, IgM antibodies are less specific than IgG antibodies and more likely to result in a false positive. For these reasons, physicians requesting IgM serologic titers should also request concurrent IgG titers.
产品亮点	Related products: Q fever ELISA Kits;

背景介绍

The reference standard test for the serologic diagnosis of acute Q fever is the indirect immunofluorescence antibody (IFA) using C. burnetii antigen, performed on paired serum samples to demonstrate a significant (fourfold or more) rise in antibody titers. The first sample should be taken as early in the disease as possible, preferably in the first week of symptoms, and the second sample should be taken 3 to 6 weeks later. In most cases of Q fever, the first IgG IFA titer is typically low, or “negative,” and the second typically shows a fourfold or greater increase in IgG antibody levels. A negative test during the first week of illness does not rule out Q fever as a cause of illness. There are two distinct antigenic phases (phase I and phase II) to which humans develop antibody responses. In acute infection, an antibody response to C. burnetii phase II antigen is predominant and is higher than antibody levels to phase I antigen; the reverse is true in chronic infection which is associated with a rising phase I IgG titer that may be higher than phase II IgG.

IgM antibodies usually rise at the same time as IgG, near the end of the first week of illness, and remain elevated for months or longer and therefore provide limited diagnostic value on their own. Furthermore, IgM antibodies are less specific than IgG antibodies and more likely to result in a false positive. For these reasons, physicians requesting IgM serologic titers should also request concurrent IgG titers.

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