Human CD155 / Poliovirus Receptor ELISA Kit
Key features and details
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- 偶联标记:
- 偶联标记说明:
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Brand:
CAT.NO. : ARG82512
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Product Details
内含物
| 货号 | 内含物名称 | 包装 | 温度 |
|---|---|---|---|
| ARG82512-001 | Antibody-coated microplate | 8 X 12 strips | 4°C. Unused strips should be sealed tightly in the air-tight pouch. |
| ARG82512-002 | Standard | 2 X 10 ng/vial | 4°C |
| ARG82512-003 | Standard/Sample diluent | 30 ml (Ready to use) | 4°C |
| ARG82512-004 | Antibody conjugate concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG82512-005 | Antibody diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG82512-006 | HRP-Streptavidin concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG82512-007 | HRP-Streptavidin diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG82512-008 | 25X Wash buffer | 20 ml | 4°C |
| ARG82512-009 | TMB substrate | 10 ml (Ready to use) | 4°C (Protect from light) |
| ARG82512-010 | STOP solution | 10 ml (Ready to use) | 4°C |
| ARG82512-011 | Plate sealer | 4 strips | Room temperature |
概述
| 产品描述 | ARG82512 Human CD155 / Poliovirus Receptor ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human CD155 / Poliovirus Receptor in serum, plasma (EDTA, heparin) and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | CD155 / Poliovirus Receptor |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 78 pg/ml |
| 样品类型 | Serum, plasma (EDTA, heparin) and cell culture supernatants. |
| 标准范围 | 156 - 10000 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: 4.8% Inter-Assay CV: 6.3% |
| 別名 | NECL5; CD antigen CD155; Nectin-like protein 5; PVS; Necl-5; HVED; Poliovirus receptor; TAGE4; NECL-5; CD155 |
应用说明
| 检测时间 | ~ 5 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PVR |
| 全名 | poliovirus receptor |
| 背景介绍 | The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| 生物功能 | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. [UniProt] |
| 细胞定位 | Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Isoform Delta: Cell membrane; Single-pass type I membrane protein. Isoform Beta: Secreted. Isoform Gamma: Secreted. [UniProt] |
| 产品亮点 | Related products: CD155 antibodies; CD155 ELISA Kits; CD155 Duos / Panels; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 翻译后修饰 | N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4. Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation. [UniProt] |
检测图片 (1)
ARG82512 Human CD155 / Poliovirus Receptor ELISA Kit standard curve image
ARG82512 Human CD155 / Poliovirus Receptor ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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