Human Dkk1 ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- Protein Full name:
- 灵敏度:
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Brand:
CAT.NO. : ARG83032
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Product Details
概述
| 产品描述 | ARG83032 Human Dkk1 ELISA Kit is an Enzyme Immunoassay kit for the quantification ofHuman Dkk1in serum, plasma (heparin), ascites, urine and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | Not cross-reacts with: Human IL2, IL4, IL5, IL6, IL8, IL10, IL12, Dkk4, Kremen1, Kremen2. Mouse Dkk4, Kremen1, Kremen2, LRP6. Rat Dkk4, Kremen1, Kremen2, LRP6. |
| 靶点名称 | DKK1 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| Protein Full name | Dickkopf-related protein 1 |
| 灵敏度 | 31.3 pg/ml |
| 样品类型 | Serum, plasma (heparin), ascites, urine and cell culture supernatants. |
| 标准范围 | 62.5 - 4000 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| 別名 | DKK1, Dickkopf WNT Signaling Pathway Inhibitor 1, SK, DKK 1, Dickkopf Related Protein 1, Dickkopf (Xenopus Laevis) Homolog 1, Dickkopf 1 Homolog (Xenopus Laevis), Dickkopf Like Protein 1, Dickkopf 1 Homolog, Dickkopf 1 Like 3, Dickkopf 1, HDkk, 1, Dkk 1 |
应用说明
| 检测时间 | ~ 4 hours |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DKK1 |
| 全名 | Dickkopf WNT Signaling Pathway Inhibitor 1 |
| 背景介绍 | This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017] |
| 生物功能 | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. [UniProt] |
| 细胞定位 | Secreted |
| 产品亮点 | Related products: DKK1 antibodies; DKK1 ELISA Kits; |
| 翻译后修饰 | Disulfide bond, Glycoprotein |
检测图片 (1)
ARG83032 Human Dkk1 ELISA Kit standard curve image
ARG83032 Human Dkk1 ELISA Kit results of standard run with optical density reading at 450 nm
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