SOX9 Rabbit Monoclonal Antibody(ARA829)
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:SOX9
-
Brand:
CAT.NO. : ARA6632
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Size:
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Product Details
Background
SOX9 has a role in sex determination and differentiation of Sertoli cells. It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Translocation of this gene can cause campomelic dysplasia. SOX9 is involved in the formation of testes from the indifferent fetal gonads. It is a major molecular component of the neuron-glia switch in developing spinal cord. During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium. These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative. It has a transcriptional regulation in melanin production in cells. Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:50-1:100 |
Overview
|
Immunogen |
Recombinant protein of human SOX9 |
|
Purification Method |
The antibody was purified by immunogen affinity chromatography |
|
Clonality |
Monoclonal |
|
Product Form |
Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA |
|
Gene Name |
SOX9 |
|
Related Name |
Transcription factor SOX-9 |
|
Gene ID (Human) |
6662 |
|
Gene ID (Mouse) |
20682 |
|
Protein ID (Human) |
P48436 |
|
Protein ID (Mouse) |
Q04887 |
Data
Immunohistochemical analysis of SOX9 staining in human breast carcinoma formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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