Spectrin Rabbit Monoclonal Antibody(ARA894)

Key features and details

Reactivity:Human, Mouse, Rat
Application:IHC
Host:Rabbit
Clonality:Monoclonal
Target:Spectrin

Brand:

CAT.NO. : ARA6721

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Size:

1mL

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Product Details

Background

Alpha Fodrin also named Spectrin. Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous α and β chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin α I and spectrin β I are present in erythrocytes, whereas spectrin α II (also designated fodrin α) and spectrin β II (also designated fodrin β) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin α II, a neuronal cytoskeleton protein.

Application

Application	Dilution Ratio
IHC-P	1:50-1:200

Overview

Antibody Type	Recombinant Rabbit monoclonal Antibody
Immunogen	Synthetic peptide within Human Alpha Fodrin aa 46-95 / 2,472
Species Reactivity	Human, Mouse, Rat
Validated Applications	WB, IHC-P
Molecular Weight	Predicted band size: 285 kDa
Positive Control	HeLa cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, rat brain tissue lysate, mouse brain tissue lysate, human liver carcinoma tissue, human pancreas tissue, mouse cerebellum tissue
Conjugation	unconjugated
RRID	AB_3070664
Form	Liquid
Concentration	1μg/ul
Storage Buffer	1*TBS (pH7.4), 0.05% BSA, 40% Glycerol, Preservative: 0.05% Sodium Azide
Isotype	IgG
Purification Method	Protein A affinity purified