5-HT (Serotonin) Rabbit Monoclonal Antibody(ARA931)

Key features and details

Reactivity:Human
Application:IHC
Host:Rabbit
Clonality:Monoclonal
Target:5-HT (Serotonin)

Brand:

CAT.NO. : ARA6769

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Size:

1mL 100μL

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Product Details

Background

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction. Serotonin is produced in the central nervous system (CNS), specifically in the brainstem's raphe nuclei, the skin's Merkel cells, pulmonary neuroendocrine cells and the tongue's taste receptor cells. Approximately 90% of the serotonin the human body produces is in the gastrointestinal tract's enterochromaffin cells, where it regulates intestinal movements. Additionally, it is stored in blood platelets and is released during agitation and vasoconstriction, where it then acts as an agonist to other platelets. About 8% is found in platelets and 1–2% in the CNS. The serotonin is secreted luminally and basolaterally, which leads to increased serotonin uptake by circulating platelets and activation after stimulation, which gives increased stimulation of myenteric neurons and gastrointestinal motility. The remainder is synthesized in serotonergic neurons of the CNS, where it has various functions, including the regulation of mood, appetite, and sleep.

Application

Application	Dilution Ratio
IHC-P	1:200-1:1000

Overview

Antibody Type	Recombinant Rabbit monoclonal Antibody
Immunogen	5-HT-OVA
Species Reactivity	Species independent
Validated Applications	WB, IHC-P, IF-Tissue, IHC-Fr, ELISA
Conjugation	unconjugated
Form	Liquid
Concentration	1μg/μl
Storage Buffer	PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Isotype	IgG
Purification Method	Protein A affinity purified