Aggrecan Rabbit Monoclonal Antibody(ARA879)

Key features and details

Reactivity:Human, Mouse, Rat
Application:IHC
Host:Rabbit
Clonality:Monoclonal
Target:Aggrecan

Brand:

CAT.NO. : ARA6706

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Size:

1mL

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Product Details

Background

The large chondroitin sulfate proteoglycan, aggrecan, is the predominant proteoglycan present in cartilage. Aggrecan is a member of the chondroitin sulphate proteoglycan family, which also includes versican/PG-M, neurocan and brevican. Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification. Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network. Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage. Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage. Brevican is a brain proteoglycan of the aggrecan/versican/neurocan family. In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a full-length form a carboxy-terminal fragment and an amino-terminal fragment.

Application

Application	Dilution Ratio
IHC-P	1:50 - 1:200

Overview

Immunogen	Recombinant protein within Human Aggrecan aa 742-981 / 2530
Species Reactivity	Human, Rat
Validated Applications	IHC-P
Molecular Weight	261 kDa
Positive Control	Rat cartilage tissue, human liver tissue
Conjugation	unconjugated
RRID	AB_3070504
Form	Liquid
Concentration	1μg/ul
Storage Buffer	1*TBS (pH7.4), 0.05% BSA, 40% Glycerol, Preservative: 0.05% Sodium Azide
Isotype	IgG
Purification Method	Protein A affinity purified