anti-5 Lipoxygenase antibody

Key features and details

  • 产品描述: Goat Polyclonal antibody recognizes 5 Lipoxygenase
  • 反应物种: Hu, Rat
  • 预测物种: Ms, Dog
  • 应用: WB
  • 宿主: Goat
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: 5 Lipoxygenase
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG64043
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Product Details
概述
产品描述Goat Polyclonal antibody recognizes 5 Lipoxygenase
反应物种Hu, Rat
预测物种Ms, Dog
应用WB
宿主Goat
克隆Polyclonal
同位型IgG
靶点名称5 Lipoxygenase
抗原物种Human
抗原C-ERNKKKQLPYYYLSPD
偶联标记Un-conjugated
別名5-lipoxygenase; Arachidonate 5-lipoxygenase; LOG5; 5-LO; EC 1.13.11.34; 5LPG; 5-LOX
应用说明
应用建议
应用推荐稀释比
WB0.3 - 1 µg/ml
应用说明WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
缓冲液Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
抗菌剂0.02% Sodium azide
稳定剂0.5% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 240 Human ALOX5

GeneID: 25290 Rat ALOX5

Swiss-port # P09917 Human Arachidonate 5-lipoxygenase

Swiss-port # P12527 Rat Arachidonate 5-lipoxygenase

背景介绍This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
研究领域Cancer antibody; Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody
预测分子量78 kDa
翻译后修饰Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.
检测图片 (1)
  • ARG64043 anti-5 Lipoxygenase antibody WB image

    Western blot: Rat Stomach lysate (35 µg protein in RIPA buffer) stained with ARG64043 anti-5 Lipoxygenase antibody at 0.3 µg/ml dilution.

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