anti-5HT2A Receptor antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG44014
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes 5HT2A Receptor |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | 5HT2A Receptor |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 1-105 of Human 5HT2A Receptor. (AYKSSQLQMGQKKNS) |
| 偶联标记 | Un-conjugated |
| 別名 | 5-HT-2; 5-HT2A; 5-HT-2A; HTR2; Serotonin receptor 2A; 5-hydroxytryptamine receptor 2A |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 53 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification. |
| 缓冲液 | PBS (pH7.3) with 0.05% proclin300 and 50% glycerol |
| 抗菌剂 | 0.05% proclin300 |
| 稳定剂 | 50% glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HTR2A |
| 全名 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled |
| 背景介绍 | This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
| 生物功能 | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Note=Localizes to the postsynaptic thickening of axo-dendritic synapses. [UniProt] |
| 预测分子量 | 53 kDa |
检测图片 (3)
ARG44014 anti-5HT2A Receptor antibody WB image
Western blot: Mouse brain with ARG44014 anti-5HT2A Receptor antibody at 1:1000 dilution.
ARG44014 anti-5HT2A Receptor antibody ICC/IF image
Immunofluorescence: Neuro-2a cells stained with ARG44014 anti-5HT2A Receptor at 1:50 dilution.
ARG44014 anti-5HT2A Receptor antibody WB image
Western blot: SH-SY5Y with ARG44014 anti-5HT2A Receptor antibody at 1:1000 dilution.
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