anti-AATF phospho (Ser477) antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes AATF phospho (Ser477)
  • 反应物种: Hu
  • 预测物种: Ms, Rat, Bov, Dog, NHuPrm, Sheep, Xenopus laevis
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: AATF
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG52244
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes AATF phospho (Ser477)
反应物种Hu
预测物种Ms, Rat, Bov, Dog, NHuPrm, Sheep, Xenopus laevis
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称AATF
抗原物种Human
抗原Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser477 conjugated to KLH
偶联标记Un-conjugated
別名BFR2; Apoptosis-antagonizing transcription factor; CHE1; CHE-1; Rb-binding protein Che-1; Protein AATF; DED
应用说明
应用建议
应用推荐稀释比
WB1:1,000
应用说明Specific for the ~66k Che-1 protein phosphorylated at Ser477. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide that was used to geneRate the antibody but not by the corresponding dephospho-peptide.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity Purified
缓冲液10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol
稳定剂0.1 mg/ml BSA, 50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 26574 Human AATF

Swiss-port # Q9NY61 Human Protein AATF

基因名称AATF
全名apoptosis antagonizing transcription factor
背景介绍Che-1, also known as AATF (apoptosis-antagonizing transcription factor), is a RNA polymerase II-binding protein involved in regulating the transcription factor E2F and promoting cell cycle progression (Burgdorf et al., 2004). It has been suggested that Che-1 may act as a neuroprotective factor against Abeta-induced apoptosis by suppressing the production of reactive oxidative species (Xie et al., 2004). The checkpoint kinase Chk2 has been shown to phosphorylate Che-1 at Ser477 contributing to the maintenance of the G2/M checkpoint induced by DNA damage (Bruno et al., 2006).
研究领域Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody
预测分子量63 kDa
翻译后修饰Hyperphosphorylated during the G1/S phase transition.
检测图片 (1)
  • ARG52244 anti-AATF phospho (Ser477) antibody WB image

    Western blot: HeLa lysate showing specific immunolabeling of the ~66k Che-1 protein phosphorylated at Ser 477 stained with ARG52244 anti-AATF phospho (Ser477) antibody.
    The phosphospecificity is shown in the second lane where immunoreactivity is blocked by preadsorption with the phospho-peptide (Peptide) used as antigen.

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