anti-ABCA4 antibody [3F4]
![anti-ABCA4 antibody [3F4]](/upload/image/products/ARG52222_IHC_210_205.jpg)
![anti-ABCA4 antibody [3F4]](/upload/image/products/ARG52222_IHC.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG52222
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [3F4] recognizes ABCA4 |
|---|---|
| 反应物种 | Hu, Ms, Bov, Xenopus laevis |
| 应用 | IHC, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 3F4 |
| 同位型 | IgG |
| 靶点名称 | ABCA4 |
| 抗原物种 | Bovine |
| 抗原 | Partially purified bovine 220-kDa disc rim protein |
| 偶联标记 | Un-conjugated |
| 別名 | STGD; RMP; RIM protein; ABC10; Stargardt disease protein; Retinal-specific ATP-binding cassette transporter; ARMD2; ATP-binding cassette sub-family A member 4; RIM ABC transporter; FFM; RP19; ABCR; STGD1; CORD3; RmP |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | Specific for ABCA4 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 背景介绍 | ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005). |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 256 kDa |
检测图片 (1)
ARG52222 anti-ABCA4 antibody [3F4] IHC image
Immunohistochemistry: adult Mouse retina showing specific immunolabeling of the ABCA4 protein stained with ARG52222 anti-ABCA4 antibody [3F4].
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