anti-ACE2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG55800
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ACE2 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms |
| 应用 | ICC/IF, IHC-P, WB |
| 特异性 | This antibody has no cross response to ACE1. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ACE2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within aa. 180-230 of Human ACE2. |
| 偶联标记 | Un-conjugated |
| 別名 | Angiotensin-converting enzyme homolog; ACEH; Angiotensin-converting enzyme 2; Metalloprotease MPROT15; ACE-related carboxypeptidase; EC 3.4.17.23 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Human Kidney Tissue Lysate | ||||||||
| 实际分子量 | ~ 105 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ACE2 |
| 全名 | angiotensin I converting enzyme 2 |
| 背景介绍 | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008] |
| 生物功能 | Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. [UniProt] |
| 产品亮点 | Related products: ACE2 antibodies; ACE2 ELISA Kits; ACE2 recombinant proteins; Anti-Rabbit IgG secondary antibodies; Related news: HMGB1, a biomarker and therapeutic target in COVID-19 ACE2, receptor of 2019-nCoV |
| 预测分子量 | 92 kDa |
| 翻译后修饰 | N-glycosylation on Asn-90 may limit SARS infectivity. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1. |
检测图片 (3)
ARG55800 anti-ACE2 antibody WB image
Western blot: Human kidney lysate stained with ARG55800 anti-ACE2 antibody at (A) 0.5, (B) 1, and (C) 2 µg/ml dilution.
ARG55800 anti-ACE2 antibody IHC-P image
Immunohistochemistry: paraffin-embedded Human kidney tissue stained with ARG55800 anti-ACE2 antibody at 2 µg/ml dilution.
ARG55800 anti-ACE2 antibody ICC/IF image
Immunofluorescence: Human Kidney cells stained with ARG55800 anti-ACE2 antibody at 20 µg/ml dilution.
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