anti-ACSL5 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes ACSL5
  • 反应物种: Hu, Ms, Rat
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: ACSL5
  • 抗原物种: Human
  • 抗原: Recombinant protein of Human ACSL5
  • Brand:
CAT.NO. : ARG55467
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes ACSL5
反应物种Hu, Ms, Rat
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称ACSL5
抗原物种Human
抗原Recombinant protein of Human ACSL5
偶联标记Un-conjugated
別名FACL5; ACS5; Long-chain-fatty-acid--CoA ligase 5; ACS2; Long-chain acyl-CoA synthetase 5; EC 6.2.1.3; LACS 5
应用说明
预测反应性说明Human, Rat
应用建议
应用推荐稀释比
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Mouse brain
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 433256 Mouse ACSL5

GeneID: 51703 Human ACSL5

GeneID: 94340 Rat ACSL5

基因名称ACSL5
全名acyl-CoA synthetase long-chain family member 5
背景介绍The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
生物功能Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. [UniProt]
研究领域Metabolism antibody; Signaling Transduction antibody
预测分子量76 kDa
检测图片 (1)
  • ARG55467 anti-ACSL5 antibody WB image

    Western blot: Mouse brain tissue lysate stained with ARG55467 anti-ACSL5 antibody.

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