anti-ADAM10 / KUZ / MADM antibody [11G2] (azide free)

Key features and details

  • 产品描述: Azide free Mouse Monoclonal antibody [11G2] recognizes ADAM10 / KUZ / MADM
  • 反应物种: Hu
  • 应用: FACS, IP, WB
  • 特异性: This antibody recognizes the ADAM-10 protein, either the 70 kDa form or the 97 kDa precursor form.
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: 11G2
  • 同位型: IgG1
  • 靶点名称: ADAM10 / KUZ / MADM
  • Brand:
CAT.NO. : ARG23353
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Product Details
概述
产品描述Azide free Mouse Monoclonal antibody [11G2] recognizes ADAM10 / KUZ / MADM
反应物种Hu
应用FACS, IP, WB
特异性This antibody recognizes the ADAM-10 protein, either the 70 kDa form or the 97 kDa precursor form.
宿主Mouse
克隆Monoclonal
克隆号11G2
同位型IgG1
靶点名称ADAM10 / KUZ / MADM
抗原物种Human
抗原Jurkat cell line
偶联标记Un-conjugated
別名Kuzbanian protein homolog; kuz; HsT18717; MADM; RAK; EC 3.4.24.81; ADAM 10; AD18; CDw156; Mammalian disintegrin-metalloprotease; CD antigen CD156c; AD10; Disintegrin and metalloproteinase domain-containing protein 10; CD156c
应用说明
应用建议
应用推荐稀释比
FACSAssay-dependent
IPAssay-dependent
WBAssay-dependent
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化说明Sterile-filtered through 0.22 µm.
缓冲液PBS
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 102 Human ADAM10

Swiss-port # O14672 Human Disintegrin and metalloproteinase domain-containing protein 10

基因名称ADAM10
全名ADAM metallopeptidase domain 10
背景介绍Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]
生物功能Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling. [UniProt]
预测分子量84 kDa
翻译后修饰The precursor is cleaved by a furin endopeptidase. [UniProt]
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