anti-ADAM15 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
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- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG43624
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ADAM15 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ADAM15 |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment corresponding to a.a. R41-R456 of Human ADAM15 |
| 偶联标记 | Un-conjugated |
| Protein Full name | Disintegrin and metalloproteinase domain-containing protein 15 |
| 別名 | ADAM 15; MDC-15; EC 3.4.24.-; Metargidin; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; Metalloprotease RGD disintegrin protein; MDC15; Disintegrin and metalloproteinase domain-containing protein 15 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q13444 Human Disintegrin and metalloproteinase domain-containing protein 15 |
|---|---|
| 基因名称 | ADAM15 |
| 全名 | ADAM metallopeptidase domain 15 |
| 背景介绍 | The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| 生物功能 | Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. [UniProt] |
| 细胞定位 | Cell junction; Cell projection; Cilium; Cytoplasmic vesicle; Flagellum; Membrane |
| 预测分子量 | ~ 110 kDa (reducing conditions) |
| 翻译后修饰 | The precursor is cleaved by a furin endopeptidase. Phosphorylation increases association with PTKs. [UniProt] |
检测图片 (2)
ARG43624 anti-ADAM15 antibody WB image
Western blot: MDA-MB-453, U-87MG, and HEK293 stained with ARG43624 anti-ADAM15 antibody at 1:5000 dilution for 1.5 hour at RT.
ARG43624 anti-ADAM15 antibody FACS image
Flow Cytometry: A431 cells stained withARG43624 anti-ADAM15 antibody at 1μg/1x106 cells ratio.
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