anti-AIRE antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG44336
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Size:
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes AIRE |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | AIRE |
| 抗原物种 | Human |
| 抗原 | E.coli-derived human AIRE recombinant protein |
| 偶联标记 | Un-conjugated |
| 別名 | APECED; Autoimmune regulator; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; AIRE1; PGA1; APECED protein |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | AIRE |
| 全名 | autoimmune regulator |
| 背景介绍 | This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012] |
| 生物功能 | Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. [UniProt] |
| 研究领域 | Gene Regulation antibody; Immune System antibody |
| 预测分子量 | 58 kDa |
| 翻译后修饰 | Phosphorylated. Phosphorylation could trigger oligomerization. |
检测图片 (4)
ARG44336 anti-AIRE antibody IHC-P image
Immunohistochemistry: Human tonsil tissue stained with ARG44336 anti-AIRE antibody at 2 μg/ml dilution.
ARG44336 anti-AIRE antibody WB image
Western blot: RT4 and HeLa stained with ARG44336 anti-AIRE antibody at 0.5 μg/ml dilution.
ARG44336 anti-AIRE antibody WB image
Western blot: Rat testis stained with ARG44336 anti-AIRE antibody at 0.5 μg/ml dilution.
ARG44336 anti-AIRE antibody WB image
Western blot: Mouse thymus stained with ARG44336 anti-AIRE antibody at 0.5 μg/ml dilution.
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