anti-ALDH2 antibody [2C10]

CAT.NO. : ARG57176

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Size:

50 μl

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Product Details

概述

产品描述	Mouse Monoclonal antibody [2C10] recognizes ALDH2
反应物种	Hu
应用	WB
宿主	Mouse
克隆	Monoclonal
克隆号	2C10
同位型	IgG2a, kappa
靶点名称	ALDH2
抗原物种	Human
抗原	Recombinant fragment around aa. 18-517 of Human ALDH2
偶联标记	Un-conjugated
別名	EC 1.2.1.3; ALDH class 2; ALDM; ALDHI; Aldehyde dehydrogenase, mitochondrial; ALDH-E2

应用说明

应用建议

应用	推荐稀释比
WB	Assay-dependent

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein A.
缓冲液	PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	10% Glycerol
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 217 Human ALDH2 Swiss-port # P05091 Human Aldehyde dehydrogenase, mitochondrial
基因名称	ALDH2
全名	aldehyde dehydrogenase 2 family (mitochondrial)
背景介绍	This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]
预测分子量	56 kDa

检测图片 (2)

ARG57176 anti-ALDH2 antibody [2C10] WB image
Western blot: 40 µg of 1) HepG2, 2) Mouse liver, and 3) Mouse lung lysates stained with ARG57176 anti-ALDH2 antibody [2C10] at 1:1000.
ARG57176 anti-ALDH2 antibody [2C10] WB image
Western blot: 40 µg of 1) 293T, and 2) ALDH2 transfected 293T cell lysate stained with ARG57176 anti-ALDH2 antibody [2C10] at 1:500.

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