anti-AMACR / p504S antibody [13H4]

Key features and details

  • 产品描述: Rabbit Monoclonal antibody [Rabbit Monoclonal 13H4] recognizes AMACR / p504S
  • 反应物种: Hu
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Monoclonal
  • 克隆号: Rabbit Monoclonal 13H4
  • 同位型: IgG
  • 靶点名称: AMACR / p504S
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG56016
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Product Details
概述
产品描述Rabbit Monoclonal antibody [Rabbit Monoclonal 13H4] recognizes AMACR / p504S
反应物种Hu
应用IHC-P, WB
宿主Rabbit
克隆Monoclonal
克隆号Rabbit Monoclonal 13H4
同位型IgG
靶点名称AMACR / p504S
抗原物种Human
抗原Full length Human AMACR recombinant protein.
偶联标记Un-conjugated
別名AMACR; Alpha-Methylacyl-CoA Racemase; P504S; RACE; 2-Methylacyl-CoA Racemase; EC 5.1.99.4; AMACRD; CBAS4; RM
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:100
WBAssay-dependent
应用说明Antigen retrieval for IHC-P: Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min.

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Unpurified high titer supernatant
缓冲液IMDM, 0.05% Sodium azide and 5% FBS
抗菌剂0.05% Sodium azide
稳定剂5% FBS
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 23600 Human AMACR

Swiss-port # Q9UHK6 Human Alpha-methylacyl-CoA racemase

基因名称AMACR
全名alpha-methylacyl-CoA racemase
背景介绍This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.
生物功能Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs.
细胞定位Mitochondrion, Peroxisome
预测分子量42 kDa
翻译后修饰Acetylation
检测图片 (2)
  • ARG56016 anti-AMACR / p504S antibody [13H4] IHC-P image

    Immunohistochemistry: Formalin-fixed, paraffin-embedded Human prostate carcinoma stained with ARG56016 anti-AMACR / p504S antibody [13H4].

  • ARG56016 anti-AMACR / p504S antibody [13H4] IHC-P image

    Immunohistochemistry: Formalin-fixed, paraffin-embedded Human prostate carcinoma stained with ARG56016 anti-AMACR / p504S antibody [13H4].

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