anti-Annexin A1 antibody [ANEX 5E4/1]
![anti-Annexin A1 antibody [ANEX 5E4/1]](/upload/image/products/ARG10540_WB_Sheet1_Rev1_160425_210_205.jpg)
![anti-Annexin A1 antibody [ANEX 5E4/1]](/upload/image/products/ARG10540_WB_Sheet1_Rev1_160425.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG10540
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [5E4/1] recognizes Annexin A1 |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, ICC/IF, IHC, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | ANEX 5E4/1 |
| 同位型 | IgG1 |
| 靶点名称 | Annexin A1 |
| 抗原物种 | Human |
| 抗原 | Mixture of native membrane proteins from human bone tissues which includes native whole annexin proteins. |
| 偶联标记 | Un-conjugated |
| 別名 | ANX1; LPC1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||||
| 阳性对照 | Endothelial cells |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 0.9 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ANXA1 |
| 全名 | annexin A1 |
| 背景介绍 | This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014] |
| 生物功能 | Annexin A1 Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). . Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca2+ and can bind up to eight Ca2+ ions (By similarity). Displays Ca2+-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). [provide by Uniprot] |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 39 kDa |
| 翻译后修饰 | Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504). Sumoylated. |
检测图片 (1)
ARG10540 anti-Annexin A1 antibody [ANEX 5E4/1] WB image
Western blot: 30 µg of HeLa cell lysate stained with ARG10540 anti-Annexin A1 antibody [ANEX 5E4/1] at 1:500 dilution.
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