anti-Antithrombin III antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
Product Details
| 产品描述 | Rabbit Polyclonal antibody recognizes Antithrombin III |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Antithrombin III |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 364-393 (C-terminus) of Human Antithrombin III. |
| 偶联标记 | Un-conjugated |
| 別名 | AT3D; Antithrombin-III; ATIII; Serpin C1; AT3; THPH7 |
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | Human blood plasma |
| 形式 | Liquid |
|---|---|
| 纯化 | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | |
|---|---|
| 基因名称 | SERPINC1 |
| 全名 | serpin peptidase inhibitor, clade C (antithrombin), member 1 |
| 背景介绍 | The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009] |
| 生物功能 | Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. [UniProt] |
| 细胞定位 | Secreted, extracellular space. |
| 预测分子量 | 53 kDa |
| 翻译后修饰 | Phosphorylated by FAM20C in the extracellular medium. |
ARG55756 anti-Antithrombin III antibody ICC/IF image
Immunofluorescence: 293 cells stained with ARG55756 anti-Antithrombin III antibody (green). DAPI (blue) for nuclear staining.
ARG55756 anti-Antithrombin III antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human hepatocarcinoma stained with ARG55756 anti-Antithrombin III antibody.
ARG55756 anti-Antithrombin III antibody WB image
Western blot: 35 µg of Human blood plasma lysate stained with ARG55756 anti-Antithrombin III antibody at 1:1000 dilution.
ARG55756 anti-Antithrombin III antibody FACS image
Flow Cytometry: HepG2 cells stained with ARG55756 anti-Antithrombin III antibody (right histogram) or without primary antibody control (left histogram), followed by incubation with FITC labelled secondary antibody.
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