anti-APOBEC3B antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
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- 克隆:
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- 靶点名称:
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- 抗原:
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Brand:
CAT.NO. : ARG57382
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes APOBEC3B |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | APOBEC3B |
| 抗原物种 | Human |
| 抗原 | Recombinant Protein of Human APOBEC3B. |
| 偶联标记 | Un-conjugated |
| 別名 | DNA dC->dU-editing enzyme APOBEC-3B; Phorbolin-1-related protein; Phorbolin-2/3; ARCD3; DJ742C19.2; bK150C2.2; A3B; PHRBNL; EC 3.5.4.-; ARP4; APOBEC1L |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | MCF7 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9UH17 Human DNA dC->dU-editing enzyme APOBEC-3B |
|---|---|
| 基因名称 | APOBEC3B |
| 全名 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
| 背景介绍 | This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] |
| 生物功能 | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. [UniProt] |
| 预测分子量 | 46 kDa |
检测图片 (1)
ARG57382 anti-APOBEC3B antibody WB image
Western blot: MCF7 cell lysate stained with ARG57382 anti-APOBEC3B antibody.
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