anti-Apolipoprotein H antibody [ID2]

产品描述: Mouse Monoclonal antibody [ID2] recognizes Apolipoprotein H.Mouse anti Human apolipoprotein H antibody, clone 1D2 recognizes the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1, APC inhibitor, activated protein C-binding protein or anticardiolipin cofactor. Apolipoprotein H is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, a process involved in the pathogenesis of recurrent miscarriage and thrombotic tendencies due to antiphospholipid syndrome.
反应物种: Hu
应用: IHC-Fr, WB
宿主: Mouse
克隆: Monoclonal
克隆号: ID2
同位型: IgG1
靶点名称: Apolipoprotein H
抗原物种: Human

CAT.NO. : ARG23528

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Size:

500 μl

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [ID2] recognizes Apolipoprotein H. Mouse anti Human apolipoprotein H antibody, clone 1D2 recognizes the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1, APC inhibitor, activated protein C-binding protein or anticardiolipin cofactor. Apolipoprotein H is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, a process involved in the pathogenesis of recurrent miscarriage and thrombotic tendencies due to antiphospholipid syndrome.
反应物种	Hu
应用	IHC-Fr, WB
宿主	Mouse
克隆	Monoclonal
克隆号	ID2
同位型	IgG1
靶点名称	Apolipoprotein H
抗原物种	Human
偶联标记	Un-conjugated
別名	Apo-H; Beta-2-glycoprotein 1; BG; B2G1; APC inhibitor; Apolipoprotein H; Anticardiolipin cofactor; B2GPI; Beta; 2; Activated protein C-binding protein; B2GP1; Beta-2-glycoprotein I

应用说明

应用建议

应用	推荐稀释比
IHC-Fr	Assay-dependent
WB	Assay-dependent

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Tissue Culture Supernatant
缓冲液	Tissue Culture Supernatant and 0.09% Sodium azide.
抗菌剂	0.09% Sodium azide
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 350 Human APOH Swiss-port # P02749 Human Beta-2-glycoprotein 1
基因名称	APOH
全名	apolipoprotein H (beta-2-glycoprotein I)
背景介绍	Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
生物功能	Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. [UniProt]
预测分子量	38 kDa
翻译后修饰	N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele. [UniProt]

检测图片 (1)

ARG23528 anti-Apolipoprotein H antibody [ID2] IHC-Fr image
Immunohistochemistry: Frozen section of an 8.6 week placenta stained with ARG23528 anti-Apolipoprotein H antibody [ID2].

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