anti-Arrestin 1 / S-Arrestin antibody [S128]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [S128] recognizes Arrestin 1 / S-Arrestin
  • 反应物种: Bov, Pig
  • 应用: ICC/IF, IHC-Fr, WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: S128
  • 同位型: IgG1
  • 靶点名称: Arrestin 1 / S-Arrestin
  • 抗原物种: Bovine
  • Brand:
CAT.NO. : ARG10696
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Product Details
概述
产品描述Mouse Monoclonal antibody [S128] recognizes Arrestin 1 / S-Arrestin
反应物种Bov, Pig
应用ICC/IF, IHC-Fr, WB
宿主Mouse
克隆Monoclonal
克隆号S128
同位型IgG1
靶点名称Arrestin 1 / S-Arrestin
抗原物种Bovine
抗原Recombinant Bovine Arrestin-1 with the first 20 aa of the C-terminus truncated.
偶联标记Un-conjugated
別名RP47; 48 kDa protein; S-arrestin; Rod photoreceptor arrestin; S-AG; Retinal S-antigen
应用说明
应用建议
应用推荐稀释比
ICC/IF1:1000
IHC-Fr1:1000
WB1:5000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purification.
缓冲液PBS and 50% Glycerol.
稳定剂50% Glycerol
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 280922 Bovine SAG

GeneID: 397151 Pig SAG

Swiss-port # P08168 Bovine S-arrestin

Swiss-port # P79260 Pig S-arrestin

基因名称SAG
全名S-antigen; retina and pineal gland (arrestin)
背景介绍Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008]
生物功能Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. [UniProt]
预测分子量45 kDa
检测图片 (2)
  • ARG10696 anti-Arrestin 1 / S-Arrestin antibody [S128] IHC-Fr image

    Immunohistochemistry: Confocal image of a pig retina frozen section stained with ARG10696 anti-Arrestin 1 / S-Arrestin antibody [S128] (green). Visual arrestin is most abundant in the outer segments (OS) and inner surface of the outer nuclear layer (ONL), and can be used to identify components of rod photoreceptor cells. (Cone photoreceptors have a different arrestin isotype). Other retinal layers are inner segments (IS), outer plexiform layer (OPL), inner nuclear layer (INL) and inner plexiform layer (IPL). The red stain is Fox2, an RNA binding nuclear protein related to Fox3 / NeuN, which stains nuclei of horizontal neurons and some other neurons in the INL and IPL. Nuclear DNA was revealed with DAPI (blue).

  • ARG10696 anti-Arrestin 1 / S-Arrestin antibody [S128] WB image

    Western blot: Bovine retinal extracts stained with ARG10696 anti-Arrestin 1 / S-Arrestin antibody [S128].

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