anti-ASGR1 / Asialoglycoprotein Receptor 1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG57352
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ASGR1 / Asialoglycoprotein Receptor 1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ASGR1 / Asialoglycoprotein Receptor 1 |
| 抗原物种 | Human |
| 抗原 | Recombinant Protein of Human ASGR1 / Asialoglycoprotein Receptor 1. |
| 偶联标记 | Un-conjugated |
| 別名 | ASGPR 1; HL-1; ASGPR; C-type lectin domain family 4 member H1; ASGPR1; Asialoglycoprotein receptor 1; Hepatic lectin H1; CLEC4H1; ASGP-R 1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Rat lung |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ASGR1 |
| 全名 | asialoglycoprotein receptor 1 |
| 背景介绍 | This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| 生物功能 | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. [UniProt] |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Phosphorylated on a cytoplasmic Ser residue. |
检测图片 (2)
ARG57352 anti-ASGR1 / Asialoglycoprotein Receptor 1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver injury stained with ARG57352 anti-ASGR1 / Asialoglycoprotein Receptor 1 antibody at 1:100 dilution.
ARG57352 anti-ASGR1 / Asialoglycoprotein Receptor 1 antibody WB image
Western blot: Rat lung lysate stained with ARG57352 anti-ASGR1 / Asialoglycoprotein Receptor 1 antibody.
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