anti-ASH2L antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes ASH2L
  • 反应物种: Hu, Ms, Rat
  • 应用: ICC/IF, IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: ASH2L
  • 抗原物种: Human
  • 抗原: Synthetic peptide derived from Human ASH2L.
  • Brand:
CAT.NO. : ARG43170
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes ASH2L
反应物种Hu, Ms, Rat
应用ICC/IF, IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称ASH2L
抗原物种Human
抗原Synthetic peptide derived from Human ASH2L.
偶联标记Un-conjugated
別名ASH2-like protein; ASH2L1; ASH2L2; Set1/Ash2 histone methyltransferase complex subunit ASH2; Bre2; ASH2
应用说明
应用建议
应用推荐稀释比
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照K562
实际分子量69, 80 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 23808 Mouse ASH2L

GeneID: 9070 Human ASH2L

Swiss-port # Q91X20 Mouse Set1/Ash2 histone methyltransferase complex subunit ASH2

Swiss-port # Q9UBL3 Human Set1/Ash2 histone methyltransferase complex subunit ASH2

基因名称ASH2L
全名ash2 (absent, small, or homeotic)-like (Drosophila)
生物功能Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). [UniProt]
细胞定位Nucleus. [UniProt]
预测分子量69 kDa
翻译后修饰Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels. [UniProt]
检测图片 (2)
  • ARG43170 anti-ASH2L antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human kideny tissue stained with ARG43170 anti-ASH2L antibody.

  • ARG43170 anti-ASH2L antibody WB image

    Western blot: K562 cell lysate stained with ARG43170 anti-ASH2L antibody.

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