anti-ATF2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG63122
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Product Details
概述
| 产品描述 | Goat Polyclonal antibody recognizes ATF2 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Cow, Rat, Dog |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ATF2 |
| 抗原物种 | Human |
| 抗原 | C-IVMAPSSQSQPSGS |
| 偶联标记 | Un-conjugated |
| 別名 | EC 2.3.1.48; Histone acetyltransferase ATF2; Activating transcription factor 2; cAMP-dependent transcription factor ATF-2; Cyclic AMP-dependent transcription factor ATF-2; CREB2; HB16; CREB-2; Cyclic AMP-responsive element-binding protein 2; cAMP-responsive element-binding protein 2; CRE-BP1; cAMP response element-binding protein CRE-BP1; TREB7 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P15336 Human Cyclic AMP-dependent transcription factor ATF-2 |
|---|---|
| 背景介绍 | This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] |
| 产品亮点 | Related Antibody Duos and Panels: ARG30227 Phospho ATF2 Antibody Panel (Total, pT69, pT71) Related products: ATF2 antibodies; ATF2 ELISA Kits; ATF2 Duos / Panels; Anti-Goat IgG secondary antibodies; |
| 研究领域 | Gene Regulation antibody; Immune System antibody |
| 预测分子量 | 55 kDa |
| 翻译后修饰 | Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4. ATM-mediated phosphorylation at Ser-490 and Ser-498 stimulates its function in DNA damage response. Phosphorylation at Ser-62, Thr-73 and Ser-121 activates its transcriptional activity. Phosphorylation at Thr-69 or Thr-71 enhances its histone acetyltransferase (HAT) activity. |
检测图片 (2)
ARG63122 anti-ATF2 antibody WB image
Western Blot: Human Placenta lysate (RIPA buffer, 35 µg total protein per lane) stained with ARG63122 anti-ATF2 antibody at 0.5 µg/ml dilution.
ARG63122 anti-ATF2 antibody WB image
Western Blot: HepG2 (A), K562 (B) and HeLa (C) nuclear lysates (35 µg protein in RIPA buffer) stained with ARG63122 anti-ATF2 antibody at 1 µg/ml dilution.
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