anti-ATP2A1 / SERCA1 ATPase antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG58315
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ATP2A1 / SERCA1 ATPase |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ATP2A1 / SERCA1 ATPase |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to a sequence at the N-terminus of Human SERCA1 ATPase (1-32aa MEAAHAKTTEECLAYFGVSETTGLTPDQVKRN), different from the related Mouse and Rat sequences by three amino acids. |
| 偶联标记 | Un-conjugated |
| 別名 | SERCA1; ATP2A; SR Ca; Endoplasmic reticulum class 1/2 Ca; EC 3.6.3.8; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; 2+ |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: By heat mediation. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q64578 Rat Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Swiss-port # Q8R429 Mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
|---|---|
| 基因名称 | ATP2A1 |
| 全名 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 |
| 背景介绍 | This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013] |
| 生物功能 | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. [UniProt] |
| 细胞定位 | Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 110 kDa |
检测图片 (3)
ARG58315 anti-ATP2A1 / SERCA1 ATPase antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat skeletal muscle stained with ARG58315 anti-ATP2A1 / SERCA1 ATPase antibody.
ARG58315 anti-ATP2A1 / SERCA1 ATPase antibody WB image
Western blot: 50 µg of Rat skeletal muscle and Mouse skeletal muscle lysates stained with ARG58315 anti-ATP2A1 / SERCA1 ATPase antibody at 0.5 µg/ml dilution.
ARG58315 anti-ATP2A1 / SERCA1 ATPase antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse skeletal muscle stained with ARG58315 anti-ATP2A1 / SERCA1 ATPase antibody.
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