anti-B Raf antibody [G11-G]
![anti-B Raf antibody [G11-G]](/upload/image/products/ARG10554_IHC_2_210_205.jpg)
![anti-B Raf antibody [G11-G]](/upload/image/products/ARG10554_IHC_1.jpg)
![anti-B Raf antibody [G11-G]](/upload/image/products/ARG10554_IHC_2.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
Product Details
| 产品描述 | Rabbit Monoclonal antibody [G11-G] recognizes B Raf |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | G11-G |
| 同位型 | IgG |
| 靶点名称 | B Raf |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around Val600 of Human B-raf. (corresponds to Val637 of Mouse or Rat B-raf). |
| 偶联标记 | Un-conjugated |
| 別名 | BRAF1; v-Raf murine sarcoma viral oncogene homolog B1; Proto-oncogene B-Raf; p94; Serine/threonine-protein kinase B-raf; RAFB1; EC 2.7.11.1; B-RAF1; NS7 |
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
|---|---|
| 缓冲液 | 20 mM Tris-HCl (pH 8.0), 0.05% Sodium azide and 20 mg/ml BSA |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 20 mg/ml BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | Swiss-port # P15056 Human Serine/threonine-protein kinase B-raf Swiss-port # P28028 Mouse Serine/threonine-protein kinase B-raf |
|---|---|
| 基因名称 | BRAF |
| 全名 | B-Raf proto-oncogene, serine/threonine kinase |
| 背景介绍 | This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. [UniProt] |
| 预测分子量 | 84 kDa |
| 翻译后修饰 | Phosphorylation at Ser-365 by SGK1 inhibits its activity. Methylation at Arg-671 decreases stability and kinase activity. Ubiquitinated by RNF149; which leads to proteasomal degradation. Polyubiquitinated at Lys-578 in response to EGF. |
ARG10554 anti-B Raf antibody [G11-G] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human epithelium and stromal cells in normal bowel mucosa tissue (4 µm sections) stained with ARG10554 anti-B Raf antibody [G11-G].
ARG10554 anti-B Raf antibody [G11-G] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human nuclei of basal cell carcinoma of the skin and dermal fibroblasts tissue (4 µm sections) stained with ARG10554 anti-B Raf antibody [G11-G].
BRAF V600E mutant colorectal cancer cells mediate local immunosuppressive microenvironment through exosomal long noncoding RNAs
WB / Human
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