anti-Bacillus anthracis lethal factor antibody [BAL0106]
![anti-Bacillus anthracis lethal factor antibody [BAL0106]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG10282
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [BAL0106] recognizes Bacillus anthracis lethal factor |
|---|---|
| 反应物种 | Bacteria |
| 应用 | ELISA |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | BAL0106 |
| 同位型 | IgG1 |
| 靶点名称 | Bacillus anthracis lethal factor |
| 抗原物种 | Bacillus |
| 抗原 | highly purified Bacillus anthracis lethal factor |
| 偶联标记 | Un-conjugated |
应用说明
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G affinity purified |
| 缓冲液 | PBS (pH 7.4) and 0.1% Sodium azide |
| 抗菌剂 | 0.1% Sodium azide |
| 浓度 | 1.0-2.0 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | pxo1_107 |
|---|---|
| 全名 | pXO1-107 |
| 生物功能 | One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates. [UniProt] |
| 研究领域 | Microbiology and Infectious Disease antibody |
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