anti-BAFF antibody [H4-C7]
![anti-BAFF antibody [H4-C7]](/upload/image/products/ARG56948_WB_1_210_205.jpg)
![anti-BAFF antibody [H4-C7]](/upload/image/products/ARG56948_FACS_1.jpg)
![anti-BAFF antibody [H4-C7]](/upload/image/products/ARG56948_WB_1.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
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- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG56948
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [H4-C7] recognizes BAFF |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | FACS, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | H4-C7 |
| 同位型 | IgG3, kappa |
| 靶点名称 | BAFF |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment around aa. 134-285 of Human BAFF. |
| 偶联标记 | Un-conjugated |
| 別名 | BLYS; TALL1; Dendritic cell-derived TNF-like molecule; THANK; DTL; TNF- and APOL-related leukocyte expressed ligand 1; TNFSF20; CD257; BLyS; Tumor necrosis factor ligand superfamily member 13B; ZTNF4; CD antigen CD257; B lymphocyte stimulator; TALL-1; BAFF; B-cell-activating factor |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9Y275 Human Tumor necrosis factor ligand superfamily member 13B |
|---|---|
| 基因名称 | TNFSF13B |
| 全名 | tumor necrosis factor (ligand) superfamily, member 13b |
| 背景介绍 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] |
| 生物功能 | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. [UniProt] |
| 预测分子量 | 31 kDa |
| 翻译后修饰 | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated. |
检测图片 (2)
ARG56948 anti-BAFF antibody [H4-C7] FACS image
Flow Cytometry: PBMC cell line stained with ARG56948 anti-BAFF antibody [H4-C7] at 2-5 µg for 1x10^6 cells (red line). Secondary antibody: Goat anti-Mouse IgG Alexa fluor 488 conjugate. Isotype control antibody was Mouse IgG (black line).
ARG56948 anti-BAFF antibody [H4-C7] WB image
Western blot: 60 µg of Rat spleen stained with ARG56948 anti-BAFF antibody [H4-C7] at 1:500.
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