anti-Bcl 6 antibody [SP155]

Key features and details

产品描述: Rabbit Monoclonal antibody [SP155] recognizes Bcl 6
反应物种: Hu
预测物种: Rat
应用: FACS, IHC-P
宿主: Rabbit
克隆: Monoclonal
克隆号: SP155
同位型: IgG
靶点名称: Bcl 6

Brand:

CAT.NO. : ARG52561

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Size:

100 μl 50 μl

Trail, Bulk size or Custom requests Please contact us

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Rabbit Monoclonal antibody [SP155] recognizes Bcl 6
反应物种	Hu
预测物种	Rat
应用	FACS, IHC-P
宿主	Rabbit
克隆	Monoclonal
克隆号	SP155
同位型	IgG
靶点名称	Bcl 6
抗原物种	Human
抗原	Synthetic peptide derived from the C-terminus of human BCL-6 protein.
偶联标记	Un-conjugated
別名	ZNF51; LAZ3; Zinc finger protein 51; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; B-cell lymphoma 6 protein; B-cell lymphoma 5 protein; BCL5; BCL6A; BCL-5; ZBTB27; BCL-6

应用说明

应用建议

应用	推荐稀释比
FACS	Assay-Dependent
IHC-P	1:100

应用说明

IHC-P: Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Incubation Time: 10 min at RT.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

阳性对照

Tonsil

属性

形式	Liquid
纯化	Purified by protein A/G
缓冲液	PBS (pH 7.6), 1% BSA and
抗菌剂
稳定剂	1% BSA
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 604 Human BCL6 Swiss-port # P41182 Human B-cell lymphoma 6 protein
背景介绍	B cell lymphoma 6 protein (Bcl-6) proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin’s lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt lymphomas and in nodular, lymphocyte predominant Hodgkin’s disease.
细胞定位	Nucleus
产品亮点	Related products: BCL6 antibodies; Anti-Rabbit IgG secondary antibodies; Related news: Lymphoma
研究领域	Cancer antibody; Gene Regulation antibody
预测分子量	79 kDa
翻译后修饰	Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway. Polyubiquitinated. Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome. Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.

检测图片 (7)

ARG52561 anti-Bcl 6 antibody [SP155] IHC-P image
Immunohistochemistry: Human Tonsil stained with ARG52561 anti-Bcl 6 antibody [SP155].
ARG52561 anti-Bcl 6 antibody [SP155] IHC-P image
Immunohistochemistry: Human B-Cell Lymphoma stained with ARG52561 anti-Bcl 6 antibody [SP155].
ARG52561 anti-Bcl 6 antibody [SP155] IHC-P image
Immunohistochemistry: Human Tonsil stained with ARG52561 anti-Bcl 6 antibody [SP155].
ARG52561 anti-Bcl 6 antibody [SP155] IHC-P image
Immunohistochemistry: Human B-Cell Lymphoma stained with ARG52561 anti-Bcl 6 antibody [SP155].
ARG52561 anti-Bcl 6 antibody [SP155] IHC-P image
Immunohistochemistry: Human HK Lymphoma stained with ARG52561 anti-Bcl 6 antibody [SP155].
ARG52561 anti-Bcl 6 antibody [SP155] IHC-P image
Immunohistochemistry: Human Follicular Lymphoma stained with ARG52561 anti-Bcl 6 antibody [SP155].
ARG52561 anti-Bcl 6 antibody [SP155] IHC-P image
Immunohistochemistry: Human Diffuse B-Cell Lymphoma stained with ARG52561 anti-Bcl 6 antibody [SP155].