anti-beta Synuclein antibody [6A10]

CAT.NO. : ARG11148

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Size:

50 μl

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Product Details

概述

产品描述	Mouse Monoclonal antibody [6A10] recognizes beta Synuclein
反应物种	Hu, Ms, Rat, Cow, Pig
应用	IHC-Fr, WB
宿主	Mouse
克隆	Monoclonal
克隆号	6A10
同位型	IgG1
靶点名称	beta Synuclein
抗原物种	Human
抗原	KLH-conjugated synthetic peptide around the C-terminal region of Human beta Synuclein. (EPEGESYEDPPQEEYQEYEPEA)
偶联标记	Un-conjugated
別名	Beta-synuclein

应用说明

应用建议

应用	推荐稀释比
IHC-Fr	1:500 - 1:1000
WB	1:1000

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

实际分子量

~ 18 kDa

属性

形式	Liquid
纯化	Purified
缓冲液	PBS, 5 mM Sodium azide and 50% Glycerol.
抗菌剂	5 mM Sodium azide
稳定剂	50% Glycerol
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 104069 Mouse SNCB GeneID: 113893 Rat SNCB GeneID: 6620 Human SNCB Swiss-port # Q16143 Human Beta-synuclein Swiss-port # Q63754 Rat Beta-synuclein Swiss-port # Q91ZZ3 Mouse Beta-synuclein More
基因名称	SNCB
全名	synuclein, beta
背景介绍	This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
生物功能	Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. [UniProt]
细胞定位	Cytoplasm. [UniProt]
预测分子量	14 kDa
翻译后修饰	Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II. [UniProt]

检测图片 (3)

ARG11148 anti-beta Synuclein antibody [6A10] IHC-Fr image
Immunohistochemistry: Frozen section of Mouse hippocampus tissue stained with ARG11148 anti-beta Synuclein antibody [6A10] (green) at 1:500 dilution, and co-stained with ARG11140 anti-Neurofilament NF-L (C-ter) antibody (red) at 1:5000 dilution. Hoechst (blue) for nuclear staining. (Sample preparation: Following transcardial perfusion of mouse with 4% paraformaldehyde, brain was post fixed for 24 hours, cut to 45 µM, and free-floating sections were stained with above antibodies.).
ARG11148 anti-beta Synuclein antibody [6A10] WB image
Western blot: Rat cortex, Rat cerebellum, Mouse cortex, Mouse cerebellum, Cow cortex and Cow cerebellum lysates stained with ARG11148 anti-beta Synuclein antibody [6A10] at 1:1000 dilution.
ARG11148 anti-beta Synuclein antibody [6A10] IHC-Fr image
Immunohistochemistry: Frozen section of Rat cerebellum tissue stained with ARG11148 anti-beta Synuclein antibody [6A10] (green) at 1:500 dilution, and co-stained with ARG11111 anti-Calbindin antibody (red) at 1:5000 dilution. Hoechst (blue) for nuclear staining. (Sample preparation: Following transcardial perfusion of rat with 4% paraformaldehyde, brain was post fixed for 24 hours, cut to 45 µM, and free-floating sections were stained with above antibodies.).

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