anti-Bid antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG20055
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Bid |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC, IP, WB |
| 特异性 | The antibody detects 22 kDa Human Bid. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Bid |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide surrounding aa. 37 of Human Bid. |
| 偶联标记 | Un-conjugated |
| 別名 | p22 BID; BID; p15 BID; p11 BID; BH3-interacting domain death agonist; p13 BID; FP497 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified Antibody |
| 缓冲液 | PBS (pH 7.2), 30% Glycerol, 0.5% BSA and 0.01% Thimerosal |
| 抗菌剂 | 0.01% Thimerosal |
| 稳定剂 | 30% Glycerol, 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P55957 Human BH3-interacting domain death agonist |
|---|---|
| 背景介绍 | Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In the animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas. |
| 产品亮点 | Related Antibody Duos and Panels: ARG30269 Apoptosis Marker Antibody Duo (Bcl2, Bid) Related products: Bid antibodies; Bid Duos / Panels; Anti-Rabbit IgG secondary antibodies; |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Apoptosis Marker antibody; Pro-apoptotic Bcl2 protein antibody |
| 预测分子量 | 22 kDa |
| 翻译后修饰 | TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products. p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation. |
检测图片 (1)
ARG20055 anti-Bid antibody WB image
Western blot: 30 µg of Jurkat cell lysate stained with ARG20055 anti-Bid antibody at 1:500 dilution.
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