anti-Bmi 1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG55885
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Bmi 1 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Bmi 1 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 281-314 (C-terminus) of Human Bmi 1. |
| 偶联标记 | Un-conjugated |
| 別名 | Polycomb complex protein BMI-1; RING finger protein 51; Polycomb group RING finger protein 4 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | COMMD3-BMI1 |
|---|---|
| 全名 | COMMD3-BMI1 readthrough |
| 背景介绍 | This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011] |
| 生物功能 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. [UniProt] |
| 细胞定位 | Nucleus. Cytoplasm. |
| 预测分子量 | 37 kDa |
| 翻译后修饰 | Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation. |
检测图片 (2)
ARG55885 anti-Bmi 1 antibody WB image
Western blot: 30 µg of HeLa and A549 cell lysates stained with ARG55885 anti-Bmi 1 antibody at 1:1000 dilution.
ARG55885 anti-Bmi 1 antibody ICC/IF image
Immunofluorescence: 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized HeLa cells stained with ARG55885 anti-Bmi 1 antibody at 1:25 dilution (green). Cytoplasmic actin is detected with Alexa Fluor® 555 conjugated with Phalloidin (red) at 1:100 dilution.
参考文献
Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells.
WB / Human
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