anti-BRMS1 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes BRMS1
  • 反应物种: Hu, Ms, Rat
  • 应用: ICC/IF, IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: BRMS1
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 90-210 of Human BRMS1 (NP_056214.1).
  • Brand:
CAT.NO. : ARG59399
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes BRMS1
反应物种Hu, Ms, Rat
应用ICC/IF, IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称BRMS1
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 90-210 of Human BRMS1 (NP_056214.1).
偶联标记Un-conjugated
別名Breast cancer metastasis-suppressor 1
应用说明
应用建议
应用推荐稀释比
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Mouse testis
实际分子量28 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 107392 Mouse BRMS1

GeneID: 25855 Human BRMS1

GeneID: 293668 Rat BRMS1

基因名称BRMS1
全名breast cancer metastasis suppressor 1
背景介绍This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
生物功能Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. [UniProt]
细胞定位Nucleus. Cytoplasm. Note=Predominantly nuclear. [UniProt]
预测分子量28 kDa
翻译后修饰Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation. [UniProt]
检测图片 (1)
  • ARG59399 anti-BRMS1 antibody WB image

    Western blot: 25 µg of Mouse testis lysate stained with ARG59399 anti-BRMS1 antibody at 1:1000 dilution.

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