anti-c-Myb antibody

Key features and details

  • 产品描述: Mouse Monoclonal antibody recognizes c-Myb
  • 反应物种: Hu
  • 应用: WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: 1279CT309.289
  • 同位型: IgG1, kappa
  • 靶点名称: c-Myb
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG40468
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Product Details
概述
产品描述Mouse Monoclonal antibody recognizes c-Myb
反应物种Hu
应用WB
宿主Mouse
克隆Monoclonal
克隆号1279CT309.289
同位型IgG1, kappa
靶点名称c-Myb
抗原物种Human
抗原KLH-conjugated recombinant protein corresponding to aa. 1-185 of Human c-Myb.
偶联标记Un-conjugated
別名Transcriptional activator Myb; Proto-oncogene c-Myb; c-myb_CDS; c-myb; Cmyb; efg
应用说明
应用建议
应用推荐稀释比
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Jurkat
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS and 0.09% (W/V) Sodium azide.
抗菌剂0.09% (W/V) Sodium azide.
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 4602 Human MYB

Swiss-port # P10242 Human Transcriptional activator Myb

基因名称MYB
全名v-myb avian myeloblastosis viral oncogene homolog
背景介绍This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
生物功能Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. [UniProt]
细胞定位Nucleus. [UniProt]
预测分子量63 - 85 kDa
翻译后修饰Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.

Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.

Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels. [UniProt]
检测图片 (1)
  • ARG40468 anti-c-Myb antibody WB image

    Western blot: 20 µg of Jurkat whole cell lysate stained with ARG40468 anti-c-Myb antibody at 1:2000 dilution.

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