anti-C1orf77 / FOP antibody

Key features and details

  • 产品描述: Rat Monoclonal antibody recognizes C1orf77 / FOP
  • 反应物种: Ms
  • 应用: IHC-P
  • 宿主: Rat
  • 克隆: Monoclonal
  • 同位型: IgG2a
  • 靶点名称: C1orf77 / FOP
  • 抗原物种: Mouse
  • 偶联标记: Un-conjugated
  • Brand:
CAT.NO. : ARG44800
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Product Details
概述
产品描述Rat Monoclonal antibody recognizes C1orf77 / FOP
反应物种Ms
应用IHC-P
宿主Rat
克隆Monoclonal
同位型IgG2a
靶点名称C1orf77 / FOP
抗原物种Mouse
偶联标记Un-conjugated
別名CHTOP; Chromatin Target Of PRMT1; SRAG; FOP; C1orf77; Small Protein Rich In Arginine And Glycine; Chromatin Target Of PRMT1 Protein; Friend Of PRMT1 Protein; DKFZP547E1010; Small Arginine- And Glycine-Rich Protein; Chromosome 1 Open Reading Frame 77; Friend Of Prmt1; C10orf77; FL-SRAG; SRAG-3; SRAG-5; Pp7704
应用说明
应用建议
应用推荐稀释比
IHC-P1:200
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Protein A purification
缓冲液PBS with 0.09% sodium azide
抗菌剂0.09% sodium azide
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
生物信息
基因名称CHTOP
全名Chromatin Target Of PRMT1
背景介绍This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]
生物功能Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity. [Uniprot]
细胞定位Nucleus. [Uniprot]
翻译后修饰Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation. [Uniprot]
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