anti-C1q antibody (FITC)
Key features and details
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CAT.NO. : ARG22491
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Product Details
概述
| 产品描述 | FITC-conjugated Sheep Polyclonal antibody recognizes C1q This antibody recognizes human C1q, a sub-component of the C1 complement component. |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-Fr |
| 宿主 | Sheep |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | C1q |
| 抗原物种 | Human |
| 抗原 | Human C1q, purified from plasma. |
| 偶联标记 | FITC |
| 別名 | Complement C1q subcomponent subunit B |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified by ion exchange chromatography. |
| 缓冲液 | PBS and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 10 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P02746 Human Complement C1q subcomponent subunit B |
|---|---|
| 基因名称 | C1QB |
| 全名 | complement component 1, q subcomponent, B chain |
| 背景介绍 | This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008] |
| 生物功能 | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [UniProt] |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | Hydroxylated on lysine and proline residues. Hydroxylated lysine residues can be glycosylated. Human C1Q contains up to 68.3 hydroxylysine-galactosylglucose residues and up to 2.5 hydroxylysine-galactose per molecule. Total percentage hydroxylysine residues glycosylated is 86.4%. |
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