anti-CACNA2D3 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG43591
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CACNA2D3 |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CACNA2D3 |
| 抗原物种 | Rat |
| 抗原 | Synthetic peptide derived from rat Cacna2d3. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Voltage-dependent calcium channel subunit alpha-2/delta-3 |
| 別名 | HSA272268; Voltage-gated calcium channel subunit alpha-2/delta-3; Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in Tris-EDTA pH9.0 for 20 min. Incubate with antibody at RT for 30-60 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse brain |
属性
| 形式 | Powder |
|---|---|
| 纯化 | Unpurified |
| 缓冲液 | Whole serum |
| 复溶 | Reconstitute in 100 μl of sterile water. When reconstituting 0.1% sodium azide or 1:1 (v/v) glycerol may be added for an additional stability. |
| 存放说明 | Storage lyophilised/reconstituted antibody at -20°C. After reconstitution, for continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store reconstituted antibody at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q8CFG5 Rat Voltage-dependent calcium channel subunit alpha-2/delta-3 Swiss-port # Q9Z1L5 Mouse Voltage-dependent calcium channel subunit alpha-2/delta-3 |
|---|---|
| 基因名称 | CACNA2D3 |
| 全名 | calcium voltage-gated channel auxiliary subunit alpha2delta 3 |
| 背景介绍 | CACNA2D3 gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
| 生物功能 | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). |
| 细胞定位 | Membrane |
| 预测分子量 | 122 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, PhosphoproteinN-glycosylatedMay be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity). |
检测图片 (1)
ARG43591 anti-anti-CACNA2D3 antibody antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Mouse brain tissue stained with ARG43591 anti-anti-CACNA2D3 antibody antibody IHC-P image at 1:1000 dilution (RT, 30 min). Antigen retrieval: Heat the slide in Tris-EDTA, pH 9.0 buffer for 20 min.
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