anti-CaMKI alpha antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes CaMKI alpha.
  • 反应物种: Hu, Ms, Rat
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: CaMKI alpha
  • 抗原物种: Human
  • 抗原: Purified recombinant protein corresponding to human CaMKI alpha.
  • Brand:
CAT.NO. : ARG43475
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes CaMKI alpha.
反应物种Hu, Ms, Rat
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称CaMKI alpha
抗原物种Human
抗原Purified recombinant protein corresponding to human CaMKI alpha.
偶联标记Un-conjugated
Protein Full nameCalcium/calmodulin-dependent protein kinase type 1
別名CAMKI
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:100
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 171503 Rat CAMK1

GeneID: 52163 Mouse CAMK1

GeneID: 8536 Human CAMK1

基因名称CAMK1
全名calcium/calmodulin-dependent protein kinase I
背景介绍Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]
生物功能Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. [UniProt]
检测图片 (4)
  • ARG43475 anti-CaMKI alpha antibody IHC-P image

    Immunohistochemistry: Human stomach stained with ARG43475 anti-CaMKI alpha antibody at 1:100 dilution.

  • ARG43475 anti-CaMKI alpha antibody WB image

    Western blot: Rat lung stained with ARG43475 anti-CaMKI alpha antibody at 1:3000 dilution.

  • ARG43475 anti-CaMKI alpha antibody IHC-P image

    Immunohistochemistry: Mouse kidney stained with ARG43475 anti-CaMKI alpha antibody at 1:100 dilution.

  • ARG43475 anti-CaMKI alpha antibody WB image

    Western blot: Mouse lung stained with ARG43475 anti-CaMKI alpha antibody at 1:3000 dilution.

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