anti-CaMKII antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes CaMKII
  • 反应物种: Hu, Ms, Rat
  • 应用: ICC/IF, IHC-P, WB
  • 特异性: This antibody detects endogenous levels of total CaMKII.
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: CaMKII
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG57482
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes CaMKII
反应物种Hu, Ms, Rat
应用ICC/IF, IHC-P, WB
特异性This antibody detects endogenous levels of total CaMKII.
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称CaMKII
抗原物种Human
抗原Synthetic peptide derived from Human CaMKII.
偶联标记Un-conjugated
別名CAMKA; CaMK-II subunit alpha; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; EC 2.7.11.17
应用说明
应用建议
应用推荐稀释比
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purified by affinity chromatography.
缓冲液PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 12322 Mouse CAMK2A

GeneID: 25400 Rat CAMK2A

GeneID: 815 Human CAMK2A

基因名称CAMK2A
全名calcium/calmodulin-dependent protein kinase II alpha
背景介绍The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
生物功能CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). [UniProt]
预测分子量54 kDa
检测图片 (3)
  • ARG57482 anti-CaMKII antibody ICC/IF image

    Immunofluorescence: PC-12 cells stained with ARG57482 anti-CaMKII antibody.

  • ARG57482 anti-CaMKII antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Mouse colon tissue stained with ARG57482 anti-CaMKII antibody.

  • ARG57482 anti-CaMKII antibody WB image

    Western blot: SH-SY5Y cell lysate stained with ARG57482 anti-CaMKII antibody at 1:1000 dilution.

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