anti-CaMKII phospho (Thr286) antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes CaMKII phospho (Thr286)
  • 反应物种: Rat
  • 预测物种: Hu, Ms, Xenopus laevis
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: CaMKII
  • 抗原物种: Rat
  • Brand:
CAT.NO. : ARG52238
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes CaMKII phospho (Thr286)
反应物种Rat
预测物种Hu, Ms, Xenopus laevis
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称CaMKII
抗原物种Rat
抗原Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr286 conjugated to KLH
偶联标记Un-conjugated
別名CAMKA; CaMK-II subunit alpha; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; EC 2.7.11.17
应用说明
应用建议
应用推荐稀释比
WB1:1,000
应用说明Specific for the ~50k α-CaM Kinase II and the ~60k β-CaM Kinase II proteins phosphorylated at Thr286. Immunolabeling is blocked by the λ-phosphatase treatment.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity Purified
缓冲液10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol
稳定剂0.1 mg/ml BSA, 50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 25400 Rat CAMK2A

Swiss-port # P11275 Rat Calcium/calmodulin-dependent protein kinase type II subunit alpha

基因名称CAMK2A/B
全名calcium/calmodulin-dependent protein kinase II alpha
背景介绍Ca2+/calmodulin-dependent protein kinase II (CaM Kinase II) is a multi-functional calcium and calmodulin-dependent protein kinase that mediates cellular responses to a wide variety of intercellular signals (Kennedy, 1998; Schulman and Hanson, 1993). CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+-homeostasis (Gleason et al., 2003; Soderling, 2000; Hudmon and Schulman, 2002). Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II (Meng et al., 2003; Picciotto et al., 1993). Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning (Elgersma et al., 2002).
研究领域Cell Biology and Cellular Response antibody; Neuroscience antibody; Signaling Transduction antibody
预测分子量54 kDa
检测图片 (1)
  • ARG52238 anti-CaMKII phospho (Thr286) antibody WB image

    Western blot: Rat cortex lysate showing phospho-specific immunolabeling of the ~50 kDa alpha-subunit and ~60 kDa beta-subunit of the CaM Kinase II protein phosphorylated at Thr 286 stained with ARG52238 anti-CaMKII phospho (Thr286) antibody.

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