anti-CaMKK alpha antibody
CAT.NO. : ARG43085
US$ Please choose
US$ Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整,请以品牌方官网实时更新的价格为准,以确保准确性。
概述
产品描述 | Rabbit Polyclonal antibody recognizes CaMKK alpha |
---|---|
反应物种 | Ms, Rat |
应用 | IHC-P, WB |
宿主 | Rabbit |
克隆 | Polyclonal |
同位型 | IgG |
靶点名称 | CaMKK alpha |
抗原物种 | Mouse |
抗原 | Synthetic peptide corresponding to aa. 10-31 of Mouse CaMKK alpha. (QDPRAELVDRVAAINVAHLEEA) |
偶联标记 | Un-conjugated |
別名 | CaMKK alpha; CAMKKA; Calcium/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase alpha; CaM-KK alpha; EC 2.7.11.17; CaM-kinase kinase 1; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-kinase IV kinase; CaMKK 1 |
应用说明
应用建议 |
| ||||||
---|---|---|---|---|---|---|---|
应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
阳性对照 | Rat brain and Mouse brain | ||||||
实际分子量 | ~ 56 kDa |
属性
形式 | Liquid |
---|---|
纯化 | Affinity purification with immunogen. |
缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
抗菌剂 | 0.05% Thimerosal and 0.05% Sodium azide |
稳定剂 | 5% BSA |
浓度 | 0.5 mg/ml |
存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
数据库连接 | Swiss-port # P97756 Rat Calcium/calmodulin-dependent protein kinase kinase 1 Swiss-port # Q8VBY2 Mouse Calcium/calmodulin-dependent protein kinase kinase 1 |
---|---|
基因名称 | CAMKK1 |
全名 | calcium/calmodulin-dependent protein kinase kinase 1, alpha |
背景介绍 | The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
生物功能 | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. [UniProt] |
细胞定位 | Cytoplasm. Nucleus. [UniProt] |
预测分子量 | 56 kDa |
翻译后修饰 | Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity). [UniProt] |
检测图片 (2)
ARG43085 anti-CaMKK alpha antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat brain tissue stained with ARG43085 anti-CaMKK alpha antibody.
ARG43085 anti-CaMKK alpha antibody WB image
Western blot: Rat brain (Lane 1, 2) and Mouse brain (Lane 3, 4) lysates stained with ARG43085 anti-CaMKK alpha antibody.
