anti-CaMKK alpha antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes CaMKK alpha
  • 反应物种: Ms, Rat
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: CaMKK alpha
  • 抗原物种: Mouse
  • 抗原: Synthetic peptide corresponding to aa. 10-31 of Mouse CaMKK alpha. (QDPRAELVDRVAAINVAHLEEA)
  • Brand:
CAT.NO. : ARG43085
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes CaMKK alpha
反应物种Ms, Rat
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称CaMKK alpha
抗原物种Mouse
抗原Synthetic peptide corresponding to aa. 10-31 of Mouse CaMKK alpha. (QDPRAELVDRVAAINVAHLEEA)
偶联标记Un-conjugated
別名CaMKK alpha; CAMKKA; Calcium/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase alpha; CaM-KK alpha; EC 2.7.11.17; CaM-kinase kinase 1; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-kinase IV kinase; CaMKK 1
应用说明
应用建议
应用推荐稀释比
IHC-P1:200 - 1:1000
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Rat brain and Mouse brain
实际分子量~ 56 kDa
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA.
抗菌剂0.05% Thimerosal and 0.05% Sodium azide
稳定剂5% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 55984 Mouse CAMKK1

GeneID: 60341 Rat CAMKK1

Swiss-port # P97756 Rat Calcium/calmodulin-dependent protein kinase kinase 1

Swiss-port # Q8VBY2 Mouse Calcium/calmodulin-dependent protein kinase kinase 1

基因名称CAMKK1
全名calcium/calmodulin-dependent protein kinase kinase 1, alpha
背景介绍The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
生物功能Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. [UniProt]
细胞定位Cytoplasm. Nucleus. [UniProt]
预测分子量56 kDa
翻译后修饰Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity). [UniProt]
检测图片 (2)
  • ARG43085 anti-CaMKK alpha antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat brain tissue stained with ARG43085 anti-CaMKK alpha antibody.

  • ARG43085 anti-CaMKK alpha antibody WB image

    Western blot: Rat brain (Lane 1, 2) and Mouse brain (Lane 3, 4) lysates stained with ARG43085 anti-CaMKK alpha antibody.

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