anti-Cardiac Troponin T antibody [1F11]
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Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
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Brand:
Product Details
| 产品描述 | Mouse Monoclonal antibody [1F11] recognizes Cardiac Troponin T |
|---|---|
| 反应物种 | Hu, Ms, Rat, Bov, Cat, Dog, Fsh, Goat, Pig, Rb |
| 应用 | ELISA, FACS, ICC/IF, IHC-P, WB |
| 特异性 | No cross-reaction with skeletal TnT. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 1F11 |
| 同位型 | IgG2b |
| 靶点名称 | Cardiac Troponin T |
| 抗原物种 | Human |
| 抗原 | free human cTnT |
| 抗原表位 | within a.a. 145-164 |
| 偶联标记 | Un-conjugated |
| 別名 | RCM3; CMPD2; LVNC6; TnTC; TnTc; CMH2; cTnT; Cardiac muscle troponin T; CMD1D; Troponin T, cardiac muscle |
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A affinity purified. |
| 缓冲液 | PBS (pH 7.4) and 0.1% Sodium azide |
| 抗菌剂 | 0.1% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | |
|---|---|
| 基因名称 | TNNT2 |
| 全名 | troponin T type 2 (cardiac) |
| 背景介绍 | The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Signaling Transduction antibody |
| 预测分子量 | 36 kDa |
| 翻译后修饰 | Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity. |
ARG10451 anti-Cardiac Troponin T antibody [1F11] WB image
Western blot: 20 μg of Rat heart lysate stained with ARG10451 anti-Cardiac Troponin T antibody [1F11] at 1:416 dilution.
ARG10451 anti-Cardiac Troponin T antibody [1F11] IHC-P image
Immunohistochemistry: Paraffin-embedded ischemic pig heart tissue stained with ARG10451 anti-Cardiac Troponin T antibody [1F11].
ARG10451 anti-Cardiac Troponin T antibody [1F11] WB image
Western blot: Bovine muscle, heart, liver, kidney and lung lysates stained with ARG10451 anti-Cardiac Troponin T antibody [1F11].
Bovine heart serves as a positive control; Other tissue samples serve as negative controls.
克隆号文献
Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development.
Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment.
WB / Mouse
High density sphere culture of adult cardiac cells increases the levels of cardiac and progenitor markers and shows signs of vasculogenesis.
IHC / Human
Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction.
IHC-P / Mouse
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy.
FACS / Mouse
Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction.
ICC/IF, IHC-Fr / Mouse
Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells.
IA / Human
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